Publication
MLH1 mismatch repair deficiency predicts exceptional response to immune checkpoint inhibition in clear-cell renal cell carcinoma
Genomic and immunohistochemical analysis identifying somatic MLH1 deficiency as a rare but robust predictor of exceptional response to immune checkpoint inhibition in clear-cell renal cell carcinoma.
Citation
Dawidek MT, Posada Calderon L, Shah PK, Mittal R, Agridag Ucpinar B, Bakouny Z, Meli K, Saad E, Saliby RM, Woo HJ, Khandwala YS, Eid M, Labaki C, Machaalani M, Coleman J, Russo P, Kotecha RR, Carlo MI, Akin O, Braun DA, Choueiri TK, Reznik E, Chen YB, Motzer RJ, Voss MH, Hakimi AA. MLH1 mismatch repair deficiency predicts exceptional response to immune checkpoint inhibition in clear-cell renal cell carcinoma. Eur Urol. 2025 Nov 4:S0302-2838(25)04721-9. doi: 10.1016/j.eururo.2025.09.4162. Epub ahead of print. PMID: 41193371.