Publications

Labaki C, Bakouny Z, Sanglier T, Saad E, Valero Martin M, Tarantino P, Schmidt AL, Shim J, Braun DA, Bouquet F, Joyce M, Machaalani M, Van Allen EM, Xie W, Tolaney SM, Choueiri TK. Novel framework for the validation of intermediate clinical endpoints in oncology real-world data. J Natl Cancer Inst. 2026 Oct 19:djag390. doi: 10.1093/jnci/djag390.

Madsen KN, Kashima S, Soulati H, Wirth L, Ito K, Yochum ZA, Moritz V, Walker J, Machaalani M, Ghali F, Kenney P, Adeniran A, Hurwitz M, Choueiri TK, Braun DA. Pharmacologic HIF-2α inhibition preserves T cell effector function in clear cell renal cell carcinoma. J Clin Invest. 2026 Oct 6:e204613. doi: 10.1172/JCI204613.

Dudipala H, Dugan AJ, Jariwala U, Ronski K, Mercer J, Saad E, El Masri J, Machaalani M, Saleh M, Viets Layng K, Yu Y, Signoretti S, Braun D, Pal SK, Choueiri TK, McKay RR. Molecular and immune correlates of lymphocyte activation gene-3 expression in renal cell carcinoma. The Oncologist. 2026;31(9):oyag317. doi: 10.1093/oncolo/oyag317.

Suissa D, Fidelle M, Reich E, Pham TN, Thomas S, Björk JR, Liu P, Zhao L, Kitaoka K, Piard E, Lebhar I, Tian AL, Thelemaque C, Alves Costa Silva C, Deutsch E, Loriot Y, Segata N, Piccinno G, Hospers GAP, Maleki Vareki S, Silverman MS, Lenehan JG, Bataille V, Boulate D, Kuznetsova T, Weersma RK, Messaoudene M, Durand S, van der Aalst CM, de Koning HJ, Schuler-Thurner B, de Vries IJM, Rafie E, Saliby RM, Machaalani M, Haferkamp S, Schilling B, Porcari S, Ciccarese C, Iacovelli R, Cremolini C, Choueiri TK, Elkrief A, Kroemer G, Heinzerling L, Chamoto K, Ianiro G, Routy B, Derosa L, Paragios N, Zitvogel L. Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling. Nature Medicine. 2026. doi: 10.1038/s41591-026-04481-9.

Saad E†, Machaalani M†, McDermott DF, Choueiri TK. The clinical landscape of HIF2α inhibitors in oncology. Nature Reviews Clinical Oncology. 2026. doi: 10.1038/s41571-026-01145-y. †Equal contribution.

Roy AM, Bakouny Z, Dizman N, Paul MA, Ozay ZI, Lal BM, Nawfal R, Eid M, El Hajj Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Xie W, Lee AJ, Choueiri TK. International Medical Graduates Representation at International Oncology Conference Meetings: An Analysis of ASCO Annual Meetings. JCO Oncol Pract. 2026 Apr;22(4):708-716. doi: 10.1200/OP-25-00067. Epub 2025 Jun 27. PMID: 40577682.

Nassar AH, Bou Farhat E, Abushukair H, Alchoueiry M, Salem S, Machaalani M, Adib E, Henske E, Babu P, Choueiri TK, Rakaee M, Busund LTR, Takabe Y, Lau SF, Rall K, Naqash AR, Jansen C, Wang X, Challa P, Tarantino P, Partridge AH, Tolaney SM, Kwiatkowski DJ, Winer EP. Molecular and clinical insights of trastuzumab deruxtecan efficacy in advanced breast cancer. JNCI. 2026 Apr 1;118(4):669-679. doi: 10.1093/jnci/djaf344. PMID: 41418409.

Yekedüz E, Bian W, Siegmund SE, Machaalani M, El Masri J, Saleh M, Saad E, Ascione L, El Halabi R, Steiner C, Mourad P, Berg SA, McGregor B, Mantia C, Ravi P, Xu W, Hirsch MS, Choueiri TK, Serzan M. Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2. Clinical Cancer Research. 2026. doi:10.1158/1078-0432.CCR-25-2871.

Alves Costa Silva C†, Machaalani M†, Saliby RM†, Zhong C, Xie W, Pasolli E, Piccinno G, Dalban C, Fidelle M, Meurisse A, Vernerey D, Lee GS, Birebent R, Saad E, Steiner C, Flippot R, Barros-Monteiro J, Segata N, Thiery-Vuillemin A, Formenti S, Kuznetsova T, Escudier B, Derosa L, Zitvogel L, Albiges L. Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma. Nature Medicine. 2026. doi:10.1038/s41591-025-04067-x. †Equal contribution.

Abu-Remaileh M, Stransky LA, Bhalerao N, Shirole NH, Jiang Q, Saad E, Machaalani M, Vigeant SM, Woldemichael H, Xu C, Lu J, Wei H, Liu Z, Sun W, Enomoto K, Choueiri TK, Pitarresi JR, Carr SA, Udeshi ND, Kaelin WG Jr. Targeting of HIF2-driven cachexia in kidney cancer. Nat Med. 2026 Jan;32(1):245-257. doi: 10.1038/s41591-025-04054-2. Epub 2025 Nov 28. Erratum in: Nat Med. 2026 Feb;32(2):766. doi: 10.1038/s41591-026-04236-6. PMID: 41315757; PMCID: PMC12823431.

Grubb T, Koochaki P, Matar S, Ghandour F, Machaalani M, Saad E, Tang C, Reznik E, Khatun J, Salem C, Dubasik N, Orlando DA, Guenther MG, Parajuli G, Srivastava RM, Martinez SR, Coker JA, Kotecha RR, Hakimi AA, Asara JM, Chan TA, Vanharanta S, Stauffer SR, Kaelin WG Jr, Signoretti S, Choueiri TK, Chakraborty AA. The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs. Nat Commun. 2025;16(1):10012. doi:10.1038/s41467-025-64983-x.

Dawidek MT, Posada Calderon L, Shah PK, Mittal R, Agridag Ucpinar B, Bakouny Z, Meli K, Saad E, Saliby RM, Woo HJ, Khandwala YS, Eid M, Labaki C, Machaalani M, Coleman J, Russo P, Kotecha RR, Carlo MI, Akin O, Braun DA, Choueiri TK, Reznik E, Chen YB, Motzer RJ, Voss MH, Hakimi AA. MLH1 mismatch repair deficiency predicts exceptional response to immune checkpoint inhibition in clear-cell renal cell carcinoma. Eur Urol. 2025 Nov 4:S0302-2838(25)04721-9. doi: 10.1016/j.eururo.2025.09.4162. Epub ahead of print. PMID: 41193371.

Sabarwal A, Machaalani M, Rawat L, Wedel J, Tabasum S, Sasamoto Y, Buerger F, Ascione J, Eid M, Semaan K, Saad E, Yang Y, Lee D, Hodi FS, Freedman ML, Lee GSM, Balan M, Choueiri TK, Pal S. Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress. Cancer Lett. 2025;633:217984. doi:10.1016/j.canlet.2025.217984.

Labaki C, Saad E, Madsen KN, Hobeika C, Bi K, Alchoueiry M, Camp S, Hou Y, Bakouny Z, Matar S, El Ahmar N, Nyman J, Zhang L, Priolo C, Rout R, Daou M, Khabibullin D, Salem S, Schindler N, Saliby RM, Meli K, Wells C, Pimenta E, Takemura K, Marji J, Eid M, Sarlemi K, Xu J, Denize T, El Hajj Chehade R, Machaalani M, Nawfal R, Khattoun W, Saleh M, El Masri J, Haddad NR, Xu W, McGregor BA, Hirsch MS, Yilmaz R, Cheng DY, McDermott DF, Signoretti S, Romee R, Choueiri TK, Braun DA. Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma. J Clin Oncol. 2025;43(23):2639-2654. doi:10.1200/JCO-25-00234.

Yekeduz E, Zarba M, Saad E, El Hajj Chehade R, Eid M, Saliby RM, Steiner C, Machaalani M, Nawfal R, Semaan K, Ürün Y, Heng DYC, Choueiri TK. Comorbidity burden and effectiveness of immunotherapy in metastatic renal cell carcinoma. Clin Genitourin Cancer. 2025;23(4):102385. doi:10.1016/j.clgc.2025.102385.

Fletcher K, Machaalani M, El Hajj Chehade R, Nassar AH, Nawfal R, Manos M, Menzies AM, Aboubakar-Nana F, Hasse JC, Pinato DJ, Johnson A, Olsson-Brown AC, Carlino MS, Malgieri A, Cortellini A, Singh A, Parikh K, Kim SY, Naqash AR, Long GV, Challa P, Choueiri TK, Sharon E, Shah S, Johnson DB. Immune checkpoint inhibitors for patients with preexisting autoimmune neurologic disorders. JAMA Netw Open. 2025;8(6):e2513727. doi:10.1001/jamanetworkopen.2025.13727.

Steiner C†, Machaalani M†, Bonventre JV, McDermott DF, Choueiri TK, Xu W. KIM-1 as a prognostic marker in renal cell carcinoma. Eur Urol Focus. 2025;11(3):432-435. doi:10.1016/j.euf.2025.06.012. †Equal contribution.

Yadav M, Sharma A, Patne K, Tabasum S, Suryavanshi J, Rawat L, Machaalani M, Eid M, Singh RP, Choueiri TK, Pal S, Sabarwal A. AXL signaling in cancer: from molecular insights to targeted therapies. Signal Transduct Target Ther. 2025;10(1):37. doi:10.1038/s41392-024-02121-7.

Xu W, Birch G, Melki A, Moritz V, Bharadwaj M, Schindler NR, Labaki C, Saliby RM, Dinh K, Horst JT, Sun M, Kashima S, Hugaboom M, Dighe A, Machaalani M, Lee GS-M, Hurwitz M, McGregor BA, Hirsch MS, Shukla SA, McDermott DF, Signoretti S, Romee R, Choueiri TK, Braun DA. Progressive natural killer cell dysfunction in advanced-stage clear-cell renal cell carcinoma and association with clinical outcomes. ESMO Open. 2025;10(2):104105. doi:10.1016/j.esmoop.2024.104105.

Machaalani M, Eid M, Semaan K, El Hajj Chehade R, Nawfal R, Baca SC, Choueiri TK. Liquid biopsy in renal cell carcinoma. Oncologist. 2024;29(10):821-823. doi:10.1093/oncolo/oyae230.

El Zarif T†, Machaalani M†, Nawfal R†, Nassar AH, Xie W, Choueiri TK, Pomerantz M. TERT Promoter Mutations Frequency Across Race, Sex, and Cancer Type. Oncologist. 2024;29(1):8-14. doi:10.1093/oncolo/oyad208. †Equal contribution

Machaalani M, El Masri J, El Ayoubi LM, Matar B. Cancer research activity in the Arab world: a 15-year bibliometric analysis. J Egypt Public Health Assoc. 2022;97(1):26. doi:10.1186/s42506-022-00120-6.

Machaalani M, Fakhry B, Zwaideh M, Mendelek K, Mahmoud N, Hammoud T, Chahine MN. Knowledge, Attitude, and Practice Toward Cardiovascular Diseases in the Lebanese Population. Global Heart. 2022;17(1):47. doi:10.5334/gh.1138.

Machaalani M, Seifeddine H, Ali A, Bitar H, Briman O, Chahine MN. Knowledge, Attitude, and Practice Toward Hypertension Among Hypertensive Patients Residing in Lebanon. Vasc Health Risk Manag. 2022;18:541-553. doi:10.2147/VHRM.S367187.

El Zarif T, Yibrin M, De Oliveira-Gomes D, Machaalani M, Nawfal R, Bittar G, Bahmad HF, Bitar N. Overcoming Therapy Resistance in Colon Cancer by Drug Repurposing. Cancers (Basel). 2022;14(9):2105. doi:10.3390/cancers14092105.

El Ayoubi LM, El Masri J, Machaalani M, El Hage S, Salameh P. Contribution of Arab World in Transplant Research: A PubMed-Based Bibliometric Analysis. Transpl Immunol. 2021;68:101432. doi:10.1016/j.trim.2021.101432.