Publication
Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling
Multi-cohort study integrating plasma metabolomics, metagenomics, and clinical data to identify metabolic determinants of immunotherapy outcomes, linking histidine with improved survival and long-chain fatty acids and succinate with worse outcomes across advanced cancer types.
Citation
Suissa D, Fidelle M, Reich E, Pham TN, Thomas S, Björk JR, Liu P, Zhao L, Kitaoka K, Piard E, Lebhar I, Tian AL, Thelemaque C, Alves Costa Silva C, Deutsch E, Loriot Y, Segata N, Piccinno G, Hospers GAP, Maleki Vareki S, Silverman MS, Lenehan JG, Bataille V, Boulate D, Kuznetsova T, Weersma RK, Messaoudene M, Durand S, van der Aalst CM, de Koning HJ, Schuler-Thurner B, de Vries IJM, Rafie E, Saliby RM, Machaalani M, Haferkamp S, Schilling B, Porcari S, Ciccarese C, Iacovelli R, Cremolini C, Choueiri TK, Elkrief A, Kroemer G, Heinzerling L, Chamoto K, Ianiro G, Routy B, Derosa L, Paragios N, Zitvogel L. Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling. Nature Medicine. 2026. doi: 10.1038/s41591-026-04481-9.