Marc Machaalani, MD
This is a little personal site I’ve enjoyed building and updating, where I share a little about my training, academic work, and interests.
About
A little about me
I earned my medical degree from Lebanese University in 2023. From 2023 to 2026, I completed a postdoctoral fellowship in genitourinary oncology at Dana-Farber Cancer Institute and Harvard Medical School, mentored by Pr. Toni K. Choueiri. I am now part of the Yale Traditional Internal Medicine Residency Program.
My research has included integrative analyses of circulating and tumor biomarkers in renal cell carcinoma, with work spanning tumor–host interactions, immune evasion, the gut microbiome, and cancer genomics. Selected publications are included below.
From 2006 to 2021, I also studied piano at the Lebanese National Higher Conservatory of Music under the tutelage of Loucine Panjarian, earning a Bachelor’s Degree with High Distinction.
Selected academic work
Selected contributions
Metabolic determinants of cancer immunotherapy outcomes
Plasma profiling identifies metabolic signals associated with immunotherapy outcomes across cancer types.
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma
A multi-cohort study connecting a circulating biomarker with clinical outcomes, gut microbiota, and immune regulation.
Targeting of HIF2-driven cachexia in kidney cancer
This study examines how HIF2 signaling contributes to weight loss and high calcium levels in clear cell kidney cancer.
Antitumor immunity in chromophobe renal cell carcinoma
Integrated single-cell and immunogenomic analyses characterize the tumor microenvironment in chromophobe kidney cancer.
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