Publication
Targeting of HIF2-driven cachexia in kidney cancer
Mechanistic and translational study demonstrating that HIF2-driven PTHLH mediates hypercalcemia and cachexia in clear cell renal cell carcinoma and is rapidly reversed by HIF2 inhibition.
Citation
Abu-Remaileh M, Stransky LA, Bhalerao N, Shirole NH, Jiang Q, Saad E, Machaalani M, Vigeant SM, Woldemichael H, Xu C, Lu J, Wei H, Liu Z, Sun W, Enomoto K, Choueiri TK, Pitarresi JR, Carr SA, Udeshi ND, Kaelin WG Jr. Targeting of HIF2-driven cachexia in kidney cancer. Nat Med. 2026 Jan;32(1):245-257. doi: 10.1038/s41591-025-04054-2. Epub 2025 Nov 28. Erratum in: Nat Med. 2026 Feb;32(2):766. doi: 10.1038/s41591-026-04236-6. PMID: 41315757; PMCID: PMC12823431.