Publication
Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2
Integrated clinical, genomic, and transcriptomic analysis of renal cell carcinoma with NF2 biallelic loss and merlin protein deficiency, demonstrating an aggressive phenotype characterized by high proliferation, immune dysfunction, frequent cell-cycle and DNA damage–response alterations, and limited benefit from immunotherapy.
Citation
Yekedüz E, Bian W, Siegmund SE, Machaalani M, El Masri J, Saleh M, Saad E, Ascione L, El Halabi R, Steiner C, Mourad P, Berg SA, McGregor B, Mantia C, Ravi P, Xu W, Hirsch MS, Choueiri TK, Serzan M. Integrative Clinical and Molecular Evaluation of Renal Cell Carcinoma with Merlin Protein Deficiency and Biallelic Loss of NF2. Clinical Cancer Research. 2026. doi:10.1158/1078-0432.CCR-25-2871.