Publication
Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress
Preclinical study demonstrating that AXL inhibition overcomes c-Met–driven therapeutic resistance in renal cancer and promotes tumor cell death through enhanced oxidative stress.
Citation
Sabarwal A, Machaalani M, Rawat L, Wedel J, Tabasum S, Sasamoto Y, Buerger F, Ascione J, Eid M, Semaan K, Saad E, Yang Y, Lee D, Hodi FS, Freedman ML, Lee GSM, Balan M, Choueiri TK, Pal S. Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress. Cancer Lett. 2025;633:217984. doi:10.1016/j.canlet.2025.217984.